Locally Acting

Kyleena® works locally to prevent pregnancy

  • The local mechanism by which continuously released LNG contributes to contraceptive effectiveness of Kyleena has not been conclusively demonstrated

Studies of Kyleena and similar LNG IUS prototypes have suggested several mechanisms that prevent pregnancy:

  • Thickening of cervical mucus preventing passage of sperm into the uterus

  • Inhibition of sperm capacitation or survival

  • Alteration of the endometrium

Kyleena® (levonorgestrel-releasing intrauterine system) 19.5 mg mechanism of action

Kyleena cannot be used for post-coital contraception or as an emergency contraceptive.

LNG=levonorgestrel